Glaucoma, apoptosis, death, and life

Balancing cell life and death: bax, apoptosis, and breast cancer.

Apoptosis and disease: a life or death decision.

Introduction Apoptosis is an evolutionarily conserved form of cell death that was first described by Kerr and colleagues in 1972 (Kerr et al, 1972). It is essential for successful embryonic development and maintains normal cellular homeostasis in adult organisms. Gainand loss-offunction models of genes in the core apoptotic pathway suggest that perturbation of cellular homeostasis can be a prim...

Life, death, the unfolded protein response and apoptosis.

The unfolded protein response (UPR) occurs in cells in response to accumulation of unfolded proteins in the endoplasmic reticulum (ER).Whenunfolded protein accumulates secondary to a mild stress, universal protein synthesis is inhibited, but then resumes upon recovery. In contrast, a more severe or persistent stress would lead to apoptosis. UPR has not been extensively studied in the heart, tho...

Depression and Quality of Life in Patients with Glaucoma

Purpose: To investigate the frequency of depression and quality of life in patients with glaucoma. Methods: This cross-sectional study included 204 patients (102 males and 102 females) with a mean age of 58.9±11.96 and a range of 40 to 85 years old. Achromatic perimetry was performed, using the HFA SITA-standard 24-2. Severity was stratified according to the Nelson Glaucoma Severity Scale (base...

Surviving apoptosis: life-death signaling in single cells.

Tissue development and homeostasis are regulated by opposing pro-survival and pro-death signals. An interesting feature of the Tumor Necrosis Factor (TNF) family of ligands is that they simultaneously activate opposing signals within a single cell via the same ligand-receptor complex. The magnitude of pro-death events such as caspase activation and pro-survival events such as Nuclear Factor (NF...